Famous film director Guido Contini struggles to find harmony in his professional and personal lives, as he engages in dramatic relationships with his wife, his mistress, his muse, his agent, and his mother.

Margot and her son Claude decide to visit her sister Pauline after she announces that she is marrying less-than-impressive Malcolm. In short order, the storm the sisters create leaves behind a mess of thrashed relationships and exposed family secrets.

In a parallel universe, young Lyra Belacqua journeys to the far North to save her best friend and other kidnapped children from terrible experiments by a mysterious organization.

As a Washington psychiatrist unearths the origin of an alien epidemic, she also discovers her son might be the only way it can be stopped.