A sick and desperate John travels to Mexico for a risky and experimental medical procedure in hopes of a miracle cure for his cancer only to discover the entire operation is a scam to defraud the most vulnerable.

Bodies are turning up around the city, each having met a uniquely gruesome demise. As the investigation proceeds, evidence points to one suspect: John Kramer, the man known as Jigsaw, who has been dead for ten years.

As a deadly battle rages over Jigsaw’s brutal legacy, a group of Jigsaw survivors gathers to seek the support of self-help guru and fellow survivor Bobby Dagen, a man whose own dark secrets unleash a new wave of terror.

Agent Strahm is dead, and FBI agent Erickson draws nearer to Hoffman. Meanwhile, a pair of insurance executives find themselves in another game set by jigsaw.

Following Jigsaw’s grisly demise, Mark Hoffman is commended as a hero, but Agent Strahm is suspicious, and delves into Hoffman’s past. Meanwhile, another group of strangers are put through a series of gruesome tests.

Despite Jigsaw’s death, and in order to save the lives of two of his colleagues, Lieutenant Rigg is forced to take part in a new game, which promises to test him to the limit.